Mequinol

Also known as 4-Methoxyphenol (p-Hydroxyanisole). Commonly used as an antioxidant and polymerization inhibitor in certain technical and nail system applications.

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Description

Mequinol is the common name for 4-Methoxyphenol, also called p-Hydroxyanisole. It is a phenolic compound used in industry as an antioxidant and a polymerization inhibitor, helping reduce unwanted oxidation and instability in sensitive systems.
In personal care, its cosmetic use is highly restricted because it has depigmenting potential on skin. For that reason, it is associated with professional artificial nail system use only, under strict concentration limits in some jurisdictions.
If you are sourcing mequinol for cosmetic-related manufacturing, treat it as a restricted material, verify local regulatory status, and follow appropriate handling and labeling practices.

FEATURES

Antioxidant support – helps reduce oxidative degradation in compatible systems.
Polymerization inhibitor – used to help control premature polymerization in reactive monomers.
High attention material – restricted for cosmetic skin use due to depigmentation potential.
Technical applications – commonly positioned for industrial and nail system use rather than skincare.

BEST FOR

Professional artificial nail systems (where permitted)
Polymer stabilization concepts
Oxidation-sensitive technical blends
R&D and lab evaluation work

Formulator tip: Do not position mequinol for leave-on skincare. If you are working in nail systems, keep within the legal limit for your market and avoid skin contact during use and handling.

FORMULATION GUIDELINES

INCI	4-Methoxyphenol
Also Known As	Mequinol, p-Hydroxyanisole, Hydroquinone Monomethyl Ether (MEHQ)
CAS	150-76-5
Type	Phenolic antioxidant / polymerization inhibitor
Solubility	Slightly soluble in water. More soluble in alcohols and many organic solvents.
Use Rate	Regulatory-limited for cosmetics in many regions. Where allowed for professional artificial nail systems, a commonly referenced limit is up to 0.02% (200 ppm) after mixing. Always verify current rules for your target market and format.
Best Phase	Phase depends on the carrier system. Typically dissolved into a compatible solvent or monomer phase before final mixing.
pH Compatibility	Not typically used as a pH-driven active. Focus on compatibility with the base and stability goals.
Temperature Tolerance	Avoid unnecessary high-heat exposure. Add under controlled conditions appropriate to your system.
Pro Tip	This is not a casual cosmetic ingredient. Treat it as a restricted material with clear internal SOPs for handling, weighing, and labeling. If your project is nail related, align usage with professional-only positioning and the relevant concentration cap for your jurisdiction.
Appearance	White to off-white crystalline solid (grade dependent)
Stability Notes	Phenolic materials can oxidize and discolor with air and light. Keep containers tightly closed and minimize repeated exposure.
Storage	Store tightly sealed in a cool, dry place, away from light and heat.